The Science
The Science
The research behind every capsule
Solamigo isn't a hopeful blend. Every active was chosen because published human research shows it helps skin stand up to the sun. Here's each ingredient in detail: what it is, the most striking finding, a plain English read on the studies, and a link to every paper so you can check it yourself.
How to read this page. The findings below come from published studies on each individual active, mostly at the doses shown in the research, not trials of the finished Solamigo product. They describe how these nutrients support normal skin function. Solamigo works alongside sunscreen, is not a sunscreen, has no SPF, and is not intended to diagnose, treat, cure or prevent any disease.
01 Vitamin B3 · The DNA repair support
Nicotinamide
660 mgOne of the most studied nutrients for how skin handles sun exposure. It helps replenish the cellular energy (ATP) that UV burns through, and supports the skin's own machinery for repairing UV damaged DNA.
Molecular structure
C₆H₆N₂OThe landmark trial · ONTRAC
In a phase 3 trial, new nonmelanoma skin cancers fell vs placebo over 12 months
23%
Fewer in the trial group
The benefit faded once people stopped taking it, which is exactly why Solamigo is built as a simple daily habit.
The ONTRAC phase 3 trial
A large, gold standard randomized trial in people with a history of skin cancer. Daily nicotinamide led to ~23% fewer new nonmelanoma skin cancers and ~20% fewer precancerous sun spots versus placebo, with no notable side effects. The effect disappeared after stopping, so protection is tied to ongoing daily use.
View studyHow it works: DNA repair
At the cellular level, nicotinamide measurably improves skin cells' ability to repair UV induced DNA damage and helps prevent the energy crash UV triggers, the mechanism behind the clinical findings above.
View studyImportant: the trial above used 1,000 mg/day in high risk patients. Solamigo provides 660 mg/day and is not a cancer treatment or preventive. We share this research to explain the ingredient, not to claim Solamigo reduces skin cancer.
02 Polypodium leucotomos · The category classic
Fern Extract
320 mgA tropical fern extract and the most studied oral photoprotectant in the world. Decades of human research show it raises the skin's threshold for UV redness, so it simply takes more sun to make the skin react.
Key actives
Phenolic acidsHealthy adults · 60 days
Far fewer people burned while taking fern extract vs placebo
4×
More burned on placebo
Four times as many people burned without the fern extract, and the skin of those taking it needed more UV before it reddened.
Sunburn & UV threshold in healthy adults
Four times as many placebo users burned (8 vs 2). The fern group needed more UV to redden the skin (a higher "minimal erythema dose") and showed less redness intensity. No safety issues over two months.
View studyUVB response & skin biomarkers
Oral fern extract suppressed UVB induced redness within ~2 hours of taking it, and skin biopsies showed fewer sunburn cells and lower UV damage markers (such as cyclobutane pyrimidine dimers).
View studyFoundational mechanism: protecting the skin's immune cells
Oral fern extract protected against acute sunburn and helped preserve Langerhans cells, the skin's immune sentinels that UV otherwise depletes. This is the study that established oral PLE as a genuine photoprotectant.
View study03 The antioxidant powerhouse
Astaxanthin
6 mgA marine carotenoid and one of nature's most potent antioxidants. It neutralises the free radicals UV generates, helping protect skin moisture, elasticity and texture over time.
Molecular structure
C₄₀H₅₂O₄16 weeks · wrinkle & moisture
Over 16 weeks, placebo skin worsened while astaxanthin held its ground
6 mg
50% more than the leading drink
Solamigo delivers 6 mg of astaxanthin, half again as much as the 4 mg in the best known sun supplement drink.
UV protection in healthy people
Daily astaxanthin raised the amount of UV needed to redden skin and reduced moisture loss in the UV exposed area versus placebo, with people reporting improvements in rough skin and texture.
View studyWrinkles & elasticity over 16 weeks
Placebo skin significantly worsened in wrinkles and moisture over the season; the astaxanthin groups did not, a protective "hold the line" effect. An inflammatory marker (IL-1α) rose in placebo but not at the higher dose.
View studyAstaxanthin, fern, nicotinamide, all in two capsules a day.
Shop Solamigo04 The blue light & eye filter
Lutein + Zeaxanthin
10 + 2 mgCarotenoids that deposit in the skin and the eye, where they act as internal "light filters." They're the reason Solamigo can speak to protection that goes beyond UV, into high energy visible and blue light, plus eye health.
Molecular structure
C₄₀H₅₆O₂Lutein photoprotection RCT
Daily lutein raised the skin's own UV threshold versus placebo
+22%
Harder to redden
Plus measurably brighter, more even skin tone, at Solamigo's exact 10 mg + 2 mg doses.
Skin tone & UV redness, at our exact dose
At precisely Solamigo's doses, daily lutein + zeaxanthin reduced UV induced redness, raised the skin's UV threshold, and significantly improved overall skin tone and luminance: brighter, more even skin, plus better elastic recovery.
View studyPhotoprotection & the eye connection
Oral lutein delivered a ~22% relative rise in the skin's photoprotective activity vs placebo. Lutein and zeaxanthin are also the best studied carotenoids for eye health, the same nutrients used in the major AREDS2 eye study.
View study05 The collagen guardian
Lycopene
10 mgThe red carotenoid from tomatoes, among the most efficient antioxidant carotenoids. It raises the skin's UV redness threshold and, at the gene level, dials down the enzymes that break collagen down.
Molecular structure
C₄₀H₅₆Dietary photoprotection
Oral lycopene cut UV induced redness over weeks of daily use
40%
Less UV redness
And at the gene level, less of the MMP-1 enzyme that breaks down collagen, the link to long term photoaging.
Molecular protection: guarding collagen
Oral lycopene reduced UVA induced expression of skin damage genes, including HO-1, ICAM-1 and MMP-1. Because MMP-1 is a key collagen degrading enzyme, this directly links lycopene to protection against photoaging.
View studyDietary photoprotection over time
Weeks of daily lycopene rich intake raised the skin's UV redness threshold, a real, if modest, layer of protection built from within and accumulating with consistent use.
View studyEvery active on this page, at meaningful doses, in one daily capsule.
Shop Solamigo06 Mixed tocopherols · The stabilizer
Vitamin E
15 mgA fat soluble antioxidant that does two jobs: it works inside the skin's own antioxidant network, and it protects the carotenoids in the formula from oxidising, so the actives stay active in the capsule and in you.
Molecular structure
C₂₉H₅₀O₂Part of the skin's antioxidant network
Vitamin E scavenges the lipid free radicals UV creates and is regenerated by vitamin C as part of the body's natural antioxidant defence. Research shows vitamin E and C together can modulate UV induced skin inflammation. In Solamigo, its primary job is twofold: antioxidant support for the skin, and keeping the astaxanthin and carotenoids stable so the whole formula stays potent.
View researchFormulated by biotechnologists
Built by the people who understand these actives at a molecular level
Solamigo was formulated by biotechnologists, led by our founder Olivia, who studied biotechnology in the UK. The brief was simple and strict: include only ingredients the research actually supports, at doses that matter, in forms the body can use. No filler, no padding, nothing added for show. The page above is the receipts.
Shop SolamigoFindings on this page come from published human studies on Solamigo's individual active ingredients, not on the finished product, and describe how these nutrients support normal skin function. Doses studied may differ from those in Solamigo. Solamigo works alongside sunscreen, is not a sunscreen, has no SPF, and does not prevent skin cancer. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.